Cardioprotective effect of chronic treatment with statins prior to percutaneous coronary intervention
نویسندگان
چکیده
منابع مشابه
Pre-Treatment with Statins for Coronary Intervention: Pleiotropy of Statins or Effect of LDL-cholesterol Reduction?
Statins inhibit hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMCoAR), consequently suppressing cholesterol biosynthesis. Animal studies, epidemiologic studies, and clinical trials all support the low-density lipoprotein (LDL) hypothesis. The benefit of these statin drugs has greatly impacted treatment of cardiovascular diseases in primary and secondary prevention. Data from the resu...
متن کاملCardioprotective Effects of Atorvastatin plus Trimetazidine in Percutaneous Coronary Intervention
OBJECTIVE To explore the effects of preoperative administration of conventional doses of atorvastatin plus trimetazidine on the myocardial injury of patients during the perioperative period of percutaneous coronary intervention (PCI). METHODOLOGY 475 cases of acute coronary syndrome patients before PCI were randomly divided into the control group (238 cases) and experimental group (237 cases)...
متن کاملEffect of statins on coronary blood flow after percutaneous coronary intervention in patients with stable coronary artery disease
AIMS Statins have favourable effects on the vascular system. However, few data are available regarding the effect of these drugs on patients undergoing percutaneous coronary intervention (PCI). We sought to determine the impact of prior statin use on coronary blood flow after PCI in patients with stable coronary artery disease (CAD) by using the corrected thrombolysis in myocardial infarction (...
متن کاملStatins and percutaneous coronary intervention: a complementary synergy.
The inclusion of statins and stents in coronary disease management during the 1980s has marked a dramatic change in the natural history of the disease. Separately, each of these therapies have progressed rapidly and have achieved a prime position in the current armamentarium. The simultaneous use of statins in patients undergoing percutaneous coronary revascularization procedures with stent imp...
متن کاملStatins and their role in pre-percutaneous coronary intervention.
Lipid-lowering therapy with statins reduces the risk of cardiovascular events in patients with coronary artery disease. Recent in vitro and in vivo studies demonstrated a low-density lipoprotein-independent action of this class of drugs, which appears to modulate endothelial function, inflammation, and thrombosis. Randomized studies showed a beneficial effect of short-term statin pretreatment i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2003
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(03)80102-x